NALCN / ATTO 594 / S185-7
NALCN / ATTO 594 / S185-7
Product Details
| Supplier | LifeSpan | |
|---|---|---|
| Catalog #: | LS-C228767 (View supplier product page) | |
| Size | 100 μg | |
| Price | $454.00 | |
| Antigen | NALCN | |
| Clone | S185-7 | |
| Host | Mouse | |
| Isotype | IgG1 | |
| Conjugate | ATTO 594 | |
| Target Species | Mouse, Rat | |
| Applications | ICC, WB | |
| Description | NALCN Antibody (aa1659-1738, clone S185-7, Atto 594) |
About NALCN and ATTO 594
| NALCN | This gene encodes a voltage-independent, nonselective cation channel which belongs to a family of voltage-gated sodium and calcium channels that regulates the resting membrane potential and excitability of neurons. This family is expressed throughout the nervous system and conducts a persistent sodium leak current that contributes to tonic neuronal excitability. The encoded protein forms a channelosome complex that includes G-protein-coupled receptors, UNC-79, UNC-80, NCA localization factor-1, and src family tyrosine kinases. Naturally occurring mutations in this gene are associated with infantile neuroaxonal dystrophy, infantile hypotonia with psychomotor retardation and characteristic facies (IHPRF) syndrome, and congenital contractures of the limbs and face with hypotonia and developmental delay (CLIFAHDD) syndrome. A knockout of the orthologous gene in mice results in paralysis with a severely disrupted respiratory rhythm, and lethality within 24 hours after birth. [provided by RefSeq, Apr 2017] | |
|---|---|---|
| ATTO 594 | ATTO 594 from ATTO-TEC has an excitation peak at 601 nm and an emission peak at 627 nm. ATTO 594 is a novel fluorescent label belonging to the class of rhodamine dyes. Characteristic features of the label are strong absorption, high fluorescence quantum yield, high thermal and photo-stability, and excellent water solubility. Thus ATTO 594 is highly suitable for single-molecule detection applications and high-resolution microscopy such as PALM, dSTORM, STED etc. Additionally the dye highly qualifies to be applied in flow cytometry (FACS), fluorescence in-situ hybridization (FISH) and many more. ATTO 594 is very hydrophilic and shows a very good water solubility. After coupling to a substrate the label carries a net electrical charge of -1. |
Citations
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