PRDM9 / Unconjugated /
PRDM9 / Unconjugated /
Product Details
| Supplier | LifeSpan | |
|---|---|---|
| Catalog #: | LS-C108106 (View supplier product page) | |
| Size | 100 μg | |
| Price | $384.00 | |
| Antigen | PRDM9 | |
| Clone | ||
| Host | Goat | |
| Isotype | IgG | |
| Conjugate | Unconjugated | |
| Target Species | Human | |
| Applications | ELISA | |
| Description | PRDM9 Antibody (aa442-453) |
About PRDM9 and Purified
| PRDM9 | The protein encoded by this gene is a zinc finger protein with histone methyltransferase activity that catalyzes histone H3 lysine 4 trimethylation (H3K4me3) during meiotic prophase. This protein contains multiple domains, including a Kruppel-associated box (KRAB) domain, an SSX repression domain (SSXRD), a PRD1-BF1 and RIZ homologous region, a subclass of SET (PR/SET) domain, and a tandem array of C2H2 zinc fingers. The zinc finger array recognizes a short sequence motif, leading to local H3K4me3, and meiotic recombination hotspot activity. The observed allelic variation alters the DNA-binding sequence specificity of the protein, resulting in distinct meiotic recombination hotspots amongst individuals and populations. Multiple alternate alleles of this gene have been described. [provided by RefSeq, Jul 2015] |
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Citations
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