Perforin Monoclonal / PE / dG9 (delta G9)

Citations: (13)
Product Details
Supplier Thermo Fisher Scientific
Catalog #: 12-9994-42 (View supplier product page)
Size 100 Tests
Price $362.00
Antigen Perforin
Clone dG9 (delta G9)
Host Mouse
Isotype IgG2b κ
Conjugate PE
Target Species Human, Porcine
Applications FC
Description Perforin Monoclonal Antibody (dG9 (delta G9)), PE, eBioscience
About Perforin and PE
Perforin This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood. [provided by RefSeq, Aug 2017]
PE Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
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PE Excitation and Emission Spectra