CD45 Monoclonal / eFluor 450 / 30-F11

Citations: (246)
Product Details
Supplier Thermo Fisher Scientific
Catalog #: 48-0451-82 (View supplier product page)
Size 100 μg
Price $284.00
Antigen CD45
Clone 30-F11
Host Rat
Isotype IgG2b κ
Conjugate eFluor 450
Target Species Mouse
Applications FC
Description CD45 Monoclonal Antibody (30-F11), eFluor 450, eBioscience
About CD45 and eFluor 450
CD45 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
eFluor 450 eFluor™ 450 (eF450) from Thermo Fisher Scientific has an excitation peak at 405 nm and an emission peak at 450 nm. It is useful in both flow cytometry and fluorescence microscopy.
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eFluor 450 Excitation and Emission Spectra