CD4 Monoclonal / Alexa Fluor 488 / GK1.5

Citations: (116)
Product Details
Supplier Thermo Fisher Scientific
Catalog #: 53-0041-82 (View supplier product page)
Size 100 μg
Price $241.00
Antigen CD4
Clone GK1.5
Host Rat
Isotype IgG2b κ
Conjugate Alexa Fluor 488
Target Species Mouse
Applications FC
Description CD4 Monoclonal Antibody (GK1.5), Alexa Fluor 488, eBioscience
About CD4 and Alexa Fluor 488
CD4 This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, May 2020]
Alexa Fluor 488 Alexa Fluor™ 488 (AF488, Alexa 488) has an excitation peak at 488 nm and an emission peak at 496 nm, and is considered a high-performance alternative to FITC. Alexa 488 is one of the most popular Alexa Fluor™ dyes and is widely used in Fluorescence Microscopy, flow cytometry, and for staining low expression markers. It is bright, highly photostable, resistant to pH changes, and less susceptible to photobleaching. Alexa 488 and is similar in size, brightness and application to DyLight™ 488, iFluor® 488 and CF®488A.
Citations
Additional
Sources
Reviews & Ratings
Submit a Review

Alexa Fluor 488 Excitation and Emission Spectra