CD25 / eFluor 450 / eBio3C7 (3C7)

Product Details
Supplier Thermo Fisher Scientific
Catalog #: 48-0253-80 (View supplier product page)
Size 25 μg
Price $120.00
Antigen CD25
Clone eBio3C7 (3C7)
Host Rat
Isotype IgG2b κ
Conjugate eFluor 450
Target Species Mouse
Applications FC
Description CD25 Monoclonal Antibody (eBio3C7 (3C7)), eFluor™ 450, eBioscience™
About CD25 and eFluor 450
CD25 The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk. [provided by RefSeq, Jul 2020]
eFluor 450 eFluor™ 450 (eF450) from Thermo Fisher Scientific has an excitation peak at 405 nm and an emission peak at 450 nm. It is useful in both flow cytometry and fluorescence microscopy.
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eFluor 450 Excitation and Emission Spectra