CD117 Monoclonal / SuperBright 600 / 2B8

Product Details
Supplier Thermo Fisher Scientific
Catalog #: 63-1171-82 (View supplier product page)
Size 100 μg
Price $373.00
Antigen CD117
Clone 2B8
Host Rat
Isotype IgG2b κ
Conjugate SuperBright 600
Target Species Mouse, Porcine
Applications FC
Description CD117 (c-Kit) Monoclonal Antibody (2B8), Super Bright 600, eBioscience
About CD117 and SuperBright 600
CD117 This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2020]
SuperBright 600 SuperBright 600 (SB600) is a fluorescent polymer with an excitation peak at 414 nm and an emission peak at 600 nm. SB600 is spectrally similar to StarBright Violet 610 and BV605. This dye is a member of the SuperBright dye family, sold by ThermoFisher Scientific under license from BD Bioscience.
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SuperBright 600 Excitation and Emission Spectra