RAB10 / Unconjugated / F8-E2

Product Details
Supplier HuaBio
Catalog #: EM1709-43 (View supplier product page)
Size 100 μl
Price $279.00
Antigen RAB10
Clone F8-E2
Host Mouse
Isotype IgG1
Conjugate Unconjugated
Target Species Human, Mouse
Applications WB, ICC
Description The Ras-related superfamily of guanine nucleotide binding proteins, which includes the Ral / Rec, Rap, R-Ras, and Rho / Rab subfamilies, exhibit 30-60% homology with Ras p21. Accumulating data suggests an important role for Rab proteins, either in endocytosis or in biosynthetic protein transport. The transport of newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves at each stage the movement of carrier vesicles, a process that appears to involve Rab protein function. The possibility that Rab proteins might also direct the exocytosis from secretory vesicles to the plasma membrane is supported by the observation that in yeast, the SEC4 protein, which is 40% homologous to Rab proteins, is associated with secretory vesicles. Several members of the Rab subfamily have been identified, each of which is found at a particular stage of a membrane transport pathway.
About RAB10 and Purified
RAB10 RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009]
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Purified Excitation and Emission Spectra