GUCY1A3 / Unconjugated / B2-G6

Product Details
Supplier HuaBio
Catalog #: EM1708-83 (View supplier product page)
Size 100 μl
Price $279.00
Antigen GUCY1A3
Clone B2-G6
Host Mouse
Isotype IgG1
Conjugate Unconjugated
Target Species Human
Applications WB, ICC, IHC, FC
Description Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble forms, known as GCS or sGC, act as receptors for nitric oxide. The membrane-bound receptor forms, known as GC, are peptide hormone receptors. GCS, a cGMP-synthesizing enzyme, is the major receptor for the neurotransmitter nitric oxide (NO). It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme containing heterodimer, consisting of one α subunit, designated GCS-α-1, and one β subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide, which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl -indazole, YC-1. YC-1 can also stimulate GCS in a NO-independent manner. Both the α and β subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of α-1/β-1 and α-2/β-1 have been identified, and both display similar enzymatic activity.
About GUCY1A3 and Purified
GUCY1A3 Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
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Purified Excitation and Emission Spectra