KDM6A / Unconjugated /

Product Details
Supplier HuaBio
Catalog #: EM1707-68 (View supplier product page)
Size 100 μl
Price $279.00
Antigen KDM6A
Clone
Host Mouse
Isotype IgG2a
Conjugate Unconjugated
Target Species Human
Applications WB, FC
Description Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code . Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' . Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A .
About KDM6A and Purified
KDM6A This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]
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Purified Excitation and Emission Spectra