FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-120-956 (View supplier product page)
	Size	30 tests in 60 µL
	Price	$145.00
	Antigen	IL-1 beta
	Clone	REA1172
	Host	Human
	Isotype	IgG1
	Conjugate	APC
	Target Species	Human
	Applications	FC
	Description	Clone REA1172 recognizes the human IL-1β protein, a proinflammatory cytokine which belongs to the interleukin 1 (IL-1) family. IL-1β is primarly produced by macrophages, but also by monocytes and dendritic cells. It is secreted as a proprotein, that is cleaved by cytosolic caspase 1 (interleukin 1 beta convertase/CASP1/ICE) to form mature IL-1β. It plays an essential role in inflammatory response, promotes cell differentiation, e.g. Tʜ17 differentiation of T cells, and is involved in other cellular activities, including apoptosis. \| Additional information: Clone REA1172 displays negligible binding to Fc receptors.

	IL-1 beta	The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2020]
	APC	Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.

$145.00
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IL-1 beta / APC / REA1172