CCR10 / Unconjugated / REA326

Citations: (6)
Product Details
Supplier Miltenyi Biotec
Catalog #: 130-122-317 (View supplier product page)
Size 100 µg in 100 µL
Price $210.00
Antigen CCR10
Clone REA326
Host Human
Isotype IgG1
Conjugate Unconjugated
Target Species Human
Applications Mass Cytometry, MICS (MACSima Imaging Cyclic Staining), IF, IHC
Description Clone REA326 recognizes the human C-C chemokine receptor type 10 (CCR10) antigen, a multi-pass membrane protein which is also known as G-protein–coupled receptor 2 (GPR2). CCR10 is expressed by various subsets of innate-like T cells that are programmed to localize to the skin during their developmental processes in the thymus. Circulating T cells might be imprinted by skin-associated antigen-presenting cells to express CCR10 for their recruitment to the skin during the local immune response. On the other hand, IgA antibody–producing B cells generated in mucosa-associated lymphoid tissues express CCR10 for their migration and maintenance at mucosal sites. CCR10 and its ligands chemokines CCL27 and CCL28 are uniquely involved in the epithelial immunity. CCL27 is up-regulated in inflamed skin, whereas CCL28 is selectively expressed in intestinal epithelium. In vitro, CCL27−CCR10 interactions mediate the preferential migration of skin-homing CLA-bearing memory T cells. Increasing evidence also found that CCR10/ligands are involved in regulation of other immune cells in epithelial immunity and are frequently exploited by epithelium-localizing or -originated cancer cells for their survival, proliferation, and evasion from immune surveillance. | Additional information: Clone REA326 displays negligible binding to Fc receptors.
About CCR10 and Purified
CCR10 Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008]
Citations
PMID 10725696
PMID 21937703
PMID 28921509
PMID 11821900
PMID 29777158
PMID 22684736
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Purified Excitation and Emission Spectra