CTIF / Unconjugated / Polyclonal

Citations: (1)
Product Details
Supplier Atlas Antibodies
Catalog #: HPA016865 (View supplier product page)
Size 100 μl
Price $439.00
Antigen CTIF
Clone Polyclonal
Host Rabbit
Isotype IgG
Conjugate Unconjugated
Target Species Human, Mouse
Applications IHC, WB, ICC/IF
Description CBP80/20-dependent translation initiation factor
About CTIF and Purified
CTIF CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009 [PubMed 19648179]).[supplied by OMIM, Dec 2009]
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Purified Excitation and Emission Spectra