FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-122-064 (View supplier product page)
	Size	30 µg in 200 µL
	Price	$205.00
	Antigen	CD94
	Clone	REA1186
	Host	Human
	Isotype	IgG1
	Conjugate	Vio Bright 515
	Target Species	Mouse
	Applications	FC
	Description	Clone REA1186 recognizes the murine CD94 antigen, an approximately 70 kDa single-pass type II transmembrane protein, which belongs to C-type lectin superfamily. CD94 associates covalently with NKG2 family members and forms disulfide bonded heterodimers. CD94-NKG2 receptors bind HLA-E, the nonclassical MHC class Ib molecule. Depending on the associated NKG2 member, CD94-NKG2 heterodimer transmits either activating or inhibitory signal. For e.g via immunoreceptor tyrosine based-inhibitory motifs (ITIMs) containing NKG2A, CD94-NKG2A heterodimers inhibit NK cell cytotoxicity. Besides NK cells, expression of CD94-NKG2 heterodimers is also shown on NK-T cells and a small percentage of CD8+ cells in most mouse strains. DBA/2J mice do not express CD94. \| Additional information: Clone REA1186 displays negligible binding to Fc receptors.

	CD94	Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]
	Vio Bright 515	Vio®Bright® B515 from Miltenyi has an excitation peak at 488 nm and an emission peak at 514. It is comparable to BB515 in flow cytometry.

$205.00
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CD94 / Vio Bright 515 / REA1186