CD36 / PE / REA1184

Citations: (1)
Product Details
Supplier Miltenyi Biotec
Catalog #: 130-122-084 (View supplier product page)
Size 150 µg in 1 mL
Price $240.00
Antigen CD36
Clone REA1184
Host Human
Isotype IgG1
Conjugate PE
Target Species Mouse
Applications FC
Description Clone REA1184 recognizes the mouse CD36 antigen, which is a 88 kDa member of the class B scavenger receptor family. CD36 is not only expressed by platelets, but also by erythroid precursors, monocytes and macrophages, certain endothelial and specialized epithelial cells. On platelets, CD36 recognition of oxidized LDL contributes to their activation and provides a link between hyperlipidemia, oxidant stress, and the prothrombotic state. Cell-derived microparticles are also major ligands for CD36 and contribute to thrombus formation. Targeting CD36 is a promising avenue for the treatment of atheroinflammatory disorders. | Additional information: Clone REA1184 displays negligible binding to Fc receptors
About CD36 and PE
CD36 The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]
PE Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
Citations
PMID 7685021
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PE Excitation and Emission Spectra