CD155 / APC / REAL423

Product Details
Supplier Miltenyi Biotec
Catalog #: 130-120-525 (View supplier product page)
Size 30 µg in 200 µL
Price $110.00
Antigen CD155
Clone REAL423
Host cell line
Isotype IgG
Conjugate APC
Target Species Mouse
Applications FC
Description Clone REAL423 is an antibody fragment derived from the full CD155 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity. | Clone REAL423 recognizes the mouse CD155 antigen, which is a 70 kDa type I transmembrane glycoprotein in the immunoglobulin superfamily. CD155, also known as poliovirus receptor (PVR), belongs to a large family of Ig molecules called nectins and nectin-like proteins, which mediate cell-cell adhesion, cell migration, and serve as entry receptors for viruses. CD155 and its family member CD112 (nectin-2) are the ligands for the activating cell-surface receptor DNAM-1 on CD8+ T cells and natural killer (NK) cells. Mouse CD155 is found on a wide variety of cells of hematopoietic origin, on CD4+ CD8+ thymocytes, regulatory T cells (Tregs), other activated T cells, NKT cells, and at cell junctions on the primary vascular endothelial cells. | The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.
About CD155 and APC
CD155 The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
APC Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
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APC Excitation and Emission Spectra