CD40 / Oligo / 5C3

Product Details
Supplier BD Biosciences
Catalog #: 940049 (View supplier product page)
Size 25 Tests
Price $400.00
Antigen CD40
Clone 5C3
Host Mouse
Isotype IgG1 κ
Conjugate Oligo
Target Species Baboon, Cynomolgus macaque, Human, Rhesus macaque
Applications Single Cell 3' Sequencing
Description Hu CD40 Olgo AHS0117 5C3 25Tst
About CD40 and Oligo
CD40 This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
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Oligo Excitation and Emission Spectra