CD40 / SuperBright 600 / 5C3
CD40 / SuperBright 600 / 5C3
Product Details
| Supplier | Thermo Fisher Scientific | |
|---|---|---|
| Catalog #: | 63-0409-41 (View supplier product page) | |
| Size | 25 Tests | |
| Price | $163.00 | |
| Antigen | CD40 | |
| Clone | 5C3 | |
| Host | Mouse | |
| Isotype | IgG1 κ | |
| Conjugate | SuperBright 600 | |
| Target Species | Human | |
| Applications | FC | |
| Description | CD40 Monoclonal Antibody (5C3), Super Bright 600, eBioscience™ |
About CD40 and SuperBright 600
| CD40 | This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014] | |
|---|---|---|
| SuperBright 600 | SuperBright 600 (SB600) is a fluorescent polymer with an excitation peak at 414 nm and an emission peak at 600 nm. SB600 is spectrally similar to StarBright Violet 610 and BV605. This dye is a member of the SuperBright dye family, sold by ThermoFisher Scientific under license from BD Bioscience. |
Images
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Normal human peripheral blood cells were stained with CD19 Monoclonal Antibody, FITC (Product # 11-0199-42) and Mouse IgG1 kappa Isotype Control, Super Bright 600 (Product # 63-4714-82) (left) or CD40 Monoclonal Antibody, Super Bright 600 (right). Cells in the lymphocyte gate were used for analysis. |
Citations
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Reviews & Ratings
SuperBright 600 Excitation and Emission Spectra
$163.00
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