CD117 Monoclonal / SuperBright 436 / 104D2
CD117 Monoclonal / SuperBright 436 / 104D2
Product Details
| Supplier | Thermo Fisher Scientific | |
|---|---|---|
| Catalog #: | 62-1178-42 (View supplier product page) | |
| Size | 100 Tests | |
| Price | $358.00 | |
| Antigen | CD117 | |
| Clone | 104D2 | |
| Host | Mouse | |
| Isotype | IgG1 κ | |
| Conjugate | SuperBright 436 | |
| Target Species | Human | |
| Applications | FC | |
| Description | CD117 (c-Kit) Monoclonal Antibody (104D2), Super Bright 436, eBioscience |
About CD117 and SuperBright 436
| CD117 | This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2020] | |
|---|---|---|
| SuperBright 436 | SuperBright 436 (SB436) is a fluorescent polymer with an excitation peak at 414 nm and an emission peak at 436 nm. SB436 is spectrally similar to StarBright Violet 440, eFluor™ 450 and Pacific Blue but can be unmixed with Brilliant™ Violet 421 on a spectral analyzer. This dye is a member of the SuperBright dye family, sold by ThermoFisher Scientific under license from BD Bioscience. |
Images
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Staining of normal human peripheral blood cells with the Human Hematopoietic Lineage Cocktail APC (Product # 22-7776-72), CD34 Monoclonal Antibody, PE (Product # 12-0349-42) and Mouse IgG1 K Isotype Control, Super Bright 436 (Product # 62-4714-82) (left) or CD117 (c-Kit) Monoclonal Antibody, Super Bright 436 (right). Lineage negative/low cells were used for analysis. |
Citations
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Reviews & Ratings
SuperBright 436 Excitation and Emission Spectra
$358.00
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