CD186 / PerCP-eFluor 710 / DANID2
CD186 / PerCP-eFluor 710 / DANID2
Product Details
| Supplier | Thermo Fisher Scientific | |
|---|---|---|
| Catalog #: | 46-9186-80 (View supplier product page) | |
| Size | 25 μg | |
| Price | $163.00 | |
| Antigen | CD186 | |
| Clone | DANID2 | |
| Host | Rat | |
| Isotype | IgG2a κ | |
| Conjugate | PerCP-eFluor 710 | |
| Target Species | Mouse | |
| Applications | FC | |
| Description | CD186 (CXCR6) Monoclonal Antibody (DANID2), PerCP-eFluor 710, eBioscience™ |
About CD186 and PerCP-eFluor 710
| CD186 | The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the CXC chemokine receptor family. This family also includes CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR7. This gene, which maps to the chemokine receptor gene cluster, is expressed in several T lymphocyte subsets and bone marrow stromal cells. The encoded protein and its exclusive ligand, chemokine ligand 16 (CCL16), are part of a signalling pathway that regulates T lymphocyte migration to various peripheral tissues (the liver, spleen red pulp, intestine, lungs, and skin) and promotes cell-cell interaction with dendritic cells and fibroblastic reticular cells. CXCR6/CCL16 also controls the localization of resident memory T lymphocytes to different compartments of the lung and maintains airway resident memory T lymphocytes, which are an important first line of defense against respiratory pathogens. The encoded protein serves as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4. [provided by RefSeq, Aug 2020] | |
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| PerCP-eFluor 710 | PerCP-eFluor™ 710 (PerCP-eF710) is a red-emitting tandem fluorophore that combines PerCP and eF710. The donor molecule, PerCP can be excited by the 488-nm blue laser and and transfers energy to the acceptor molecule, eF710, which emitts light that can be captured with a 695/40 nm bandpass filter. PerCP-eF710 has an excitation peak at 482 nm and an emission peak at 710 nm, and is considered a slightly-red shifted but brighter alternative to PerCP-Cy5.5. This dye and associated products are mostly used for flow cytometry. This dye is part of the larger eFluor™ dye family, developed by eBioscience which is now part of ThermoFisher Scientific. |
Images
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C57BL/6 mouse splenocytes were stained with CD3 Monoclonal Antibody, FITC (Product # 11-0031-82), CD69 Monoclonal Antibody, Super Bright 436 (Product # 62-0691-82) and 0.5 µg of Rat IgG2a kappa Isotype Control, PerCP-eFluor 710 (Product # 46-4321-82) (left) or 0.5 µg of CD186 (CXCR6) Monoclonal Antibody, PerCP-eFluor 710 (right). Cells in the CD3+ gate were used for analysis. |
Citations
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Reviews & Ratings
PerCP-eFluor 710 Excitation and Emission Spectra
$163.00
Supplier Page
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