CD19 Monoclonal / SuperBright 645 / SJ25C1
CD19 Monoclonal / SuperBright 645 / SJ25C1
Product Details
| Supplier | Thermo Fisher Scientific | |
|---|---|---|
| Catalog #: | 64-0198-42 (View supplier product page) | |
| Size | 100 Tests | |
| Price | $378.00 | |
| Antigen | CD19 | |
| Clone | SJ25C1 | |
| Host | Mouse | |
| Isotype | IgG1 κ | |
| Conjugate | SuperBright 645 | |
| Target Species | Human | |
| Applications | FC | |
| Description | CD19 Monoclonal Antibody (SJ25C1), Super Bright 645, eBioscience |
About CD19 and SuperBright 645
| CD19 | This gene encodes a member of the immunoglobulin gene superfamily. Expression of this cell surface protein is restricted to B cell lymphocytes. This protein is a reliable marker for pre-B cells but its expression diminishes during terminal B cell differentiation in antibody secreting plasma cells. The protein has two N-terminal extracellular Ig-like domains separated by a non-Ig-like domain, a hydrophobic transmembrane domain, and a large C-terminal cytoplasmic domain. This protein forms a complex with several membrane proteins including complement receptor type 2 (CD21) and tetraspanin (CD81) and this complex reduces the threshold for antigen-initiated B cell activation. Activation of this B-cell antigen receptor complex activates the phosphatidylinositol 3-kinase signalling pathway and the subsequent release of intracellular stores of calcium ions. This protein is a target of chimeric antigen receptor (CAR) T-cells used in the treatment of lymphoblastic leukemia. Mutations in this gene are associated with the disease common variable immunodeficiency 3 (CVID3) which results in a failure of B-cell differentiation and impaired secretion of immunoglobulins. CVID3 is characterized by hypogammaglobulinemia, an inability to mount an antibody response to antigen, and recurrent bacterial infections. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2020] | |
|---|---|---|
| SuperBright 645 | SuperBright 645 (SB645) is a fluorescent polymer with an excitation peak at 414 nm and an emission peak at 645 nm. SB645 is spectrally similar to StarBright Violet 670 and BV650. This dye is a member of the SuperBright dye family, sold by ThermoFisher Scientific under license from BD Bioscience. |
Images
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Normal human peripheral blood cells cells were stained with CD3 Monoclonal Antibody, FITC (Product # 11-0038-80) and Mouse IgG1 kappa Isotype Control, Super Bright 645 (Product # 64-4714-82) (left) or CD19 Monoclonal Antibody, Super Bright 645 (right). Cells in the lymphocyte gate were used for analysis. |
Citations
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Reviews & Ratings
SuperBright 645 Excitation and Emission Spectra
$378.00
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