53BP1 / Unconjugated /

Product Details
Supplier St John's Laboratory
Catalog #: STJ28324-50μl (View supplier product page)
Size 50 μl
Price $248.00
Antigen 53BP1
Clone
Host Rabbit
Isotype IgG
Conjugate Unconjugated
Target Species Human, Mouse, Rat
Applications WB, IHC, IF
Description Rabbit polyclonal to TP53BP1
About 53BP1 and Purified
53BP1 This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
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Purified Excitation and Emission Spectra