PTPN1 / DyLight 488 / OTI1D10

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-73729G (View supplier product page)
Size 0.1 ml
Price $679.00
Antigen PTPN1
Clone OTI1D10
Host Mouse
Isotype IgG2a
Conjugate DyLight 488
Target Species Canine, Human, Monkey
Applications WB, FC, IHC, ICC/IF, Knockout Validated
Description Mouse PTP1B/PTPN1 antibody [DyLight 488] detects Human, Canine, Monkey
About PTPN1 and DyLight 488
PTPN1 The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
DyLight 488 DyLight™ 488 has an excitation peak at 493 nm and an emission peak at 518 nm and is spectrally similar to Alexa Fluor™ 488, fluorescein and FITC. DyLight™ 488 is most commonly used in flow cytometery, and fluorescence microscopy applications.
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DyLight 488 Excitation and Emission Spectra