PCNA / Janelia Fluor 549 / PC10

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NB500-106JF549 (View supplier product page)
Size 0.1 ml
Price $549.00
Antigen PCNA
Clone PC10
Host Mouse
Isotype IgG2a κ
Conjugate Janelia Fluor 549
Target Species Chicken, Drosophila, Fish, Human, Mouse, Porcine, Primate, Rabbit, Rat, Yeast, Zebrafish
Applications FC, IHC, ICC/IF, IHC-P, IHC-Fr
Description Specific for PCNA p36 protein expressed at high levels in proliferating cells.
About PCNA and Janelia Fluor 549
PCNA The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]
Janelia Fluor 549 Janelia Fluor® 549 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 549 has an excitation peak at 549 nm and an emission peak at 571 nm.
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Janelia Fluor 549 Excitation and Emission Spectra