Nse2 / Alexa Fluor 488 / OTI6A6

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-73070AF488 (View supplier product page)
Size 0.1 ml
Price $679.00
Antigen Nse2
Clone OTI6A6
Host Mouse
Isotype IgG2a
Conjugate Alexa Fluor 488
Target Species Human
Applications WB, FC, ICC/IF
Description Mouse Nse2 antibody [Alexa Fluor 488] detects Human
About Nse2 and Alexa Fluor 488
Nse2 This gene encodes a member of a family of E3 small ubiquitin-related modifier (SUMO) ligases that mediates the attachment of a SUMO protein to proteins involved in nuclear transport, transcription, chromosome segregation and DNA repair. The encoded protein is part of the structural maintenance of chromosomes (SMC) 5/6 complex which plays a key role genome maintenance, facilitating chromosome segregation and suppressing mitotic recombination. A knockout of the orthologous mouse gene is lethal prior to embryonic day 10.5. Naturally occurring mutations in this gene, that abolish the SUMO ligase activity, are associated with primordial dwarfism and extreme insulin resistance. [provided by RefSeq, Mar 2017]
Alexa Fluor 488 Alexa Fluor™ 488 (AF488, Alexa 488) has an excitation peak at 488 nm and an emission peak at 496 nm, and is considered a high-performance alternative to FITC. Alexa 488 is one of the most popular Alexa Fluor™ dyes and is widely used in Fluorescence Microscopy, flow cytometry, and for staining low expression markers. It is bright, highly photostable, resistant to pH changes, and less susceptible to photobleaching. Alexa 488 and is similar in size, brightness and application to DyLight™ 488, iFluor® 488 and CF®488A.
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Alexa Fluor 488 Excitation and Emission Spectra