MDM4 / Janelia Fluor 549 / OTI4G5

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-72605JF549 (View supplier product page)
Size 0.1 ml
Price $679.00
Antigen MDM4
Clone OTI4G5
Host Mouse
Isotype IgG2b
Conjugate Janelia Fluor 549
Target Species Human
Applications IHC, ICC/IF
Description Mouse MDMX antibody [Janelia Fluor 549] detects Human
About MDM4 and Janelia Fluor 549
MDM4 This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
Janelia Fluor 549 Janelia Fluor® 549 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 549 has an excitation peak at 549 nm and an emission peak at 571 nm.
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Janelia Fluor 549 Excitation and Emission Spectra