Fbxw7 / Alexa Fluor 700 / OTI6F5

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-71995AF700 (View supplier product page)
Size 0.1 ml
Price $679.00
Antigen Fbxw7
Clone OTI6F5
Host Mouse
Isotype IgG2a
Conjugate Alexa Fluor 700
Target Species Human
Applications WB, IHC
Description Mouse FBXW7/Cdc4 antibody [Alexa Fluor 700] reacts with Human
About Fbxw7 and Alexa Fluor 700
Fbxw7 This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Alexa Fluor 700 Alexa Fluor™ 700 (AF700, Alexa 700) has an excitation peak at 702 nm and an emission peak at 723 nm, and is spectrally similar to iFluor® 680 (ATT Bioquest) and iFluor® 700 (ATT Bioquest). Alexa 700 is commonly used in Flow Cytometry and is similar in size, brightness and application to iFluor® 700 and Vio® R720.
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Alexa Fluor 700 Excitation and Emission Spectra