Bcl-10 / Alexa Fluor 488 / OTI4A8

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-71398AF488 (View supplier product page)
Size 0.1 ml
Price $679.00
Antigen Bcl-10
Clone OTI4A8
Host Mouse
Isotype IgG1
Conjugate Alexa Fluor 488
Target Species Human
Applications WB, FC, IHC, ICC/IF
Description Mouse Bcl-10 antibody reacts with Human [Alexa Fluor 488]
About Bcl-10 and Alexa Fluor 488
Bcl-10 This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Alexa Fluor 488 Alexa Fluor™ 488 (AF488, Alexa 488) has an excitation peak at 488 nm and an emission peak at 496 nm, and is considered a high-performance alternative to FITC. Alexa 488 is one of the most popular Alexa Fluor™ dyes and is widely used in Fluorescence Microscopy, flow cytometry, and for staining low expression markers. It is bright, highly photostable, resistant to pH changes, and less susceptible to photobleaching. Alexa 488 and is similar in size, brightness and application to DyLight™ 488, iFluor® 488 and CF®488A.
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Alexa Fluor 488 Excitation and Emission Spectra