ATM / Janelia Fluor 646 / 10H11.E12

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NB100-306JF646 (View supplier product page)
Size 0.1 ml
Price $519.00
Antigen ATM
Clone 10H11.E12
Host Mouse
Isotype IgG1 κ
Conjugate Janelia Fluor 646
Target Species Canine (Negative), Human, Mouse, Rat
Applications IHC, ICC/IF, IHC-P
Description Mouse ATM antibody reacts with Human, Mouse, Rat, Canine (Negative) [Janelia Fluor 646]
About ATM and Janelia Fluor 646
ATM The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
Janelia Fluor 646 Janelia Fluor® 646 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 646 has an excitation peak at 646 nm and an emission peak at 664 nm.
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Janelia Fluor 646 Excitation and Emission Spectra