AIPL1 / Alexa Fluor 647 / OTI3B4

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-71775AF647 (View supplier product page)
Size 0.1 ml
Price $679.00
Antigen AIPL1
Clone OTI3B4
Host Mouse
Isotype IgG1
Conjugate Alexa Fluor 647
Target Species Human
Applications WB, FC, IHC, ICC/IF
Description Mouse AIPL1 antibody [Alexa Fluor 647] reacts with Human
About AIPL1 and Alexa Fluor 647
AIPL1 Leber congenital amaurosis (LCA) is the most severe inherited retinopathy with the earliest age of onset and accounts for at least 5% of all inherited retinal diseases. Affected individuals are diagnosed at birth or in the first few months of life with nystagmus, severely impaired vision or blindness and an abnormal or flat electroretinogram. The photoreceptor/pineal-expressed gene, AIPL1, encoding aryl-hydrocarbon interacting protein-like 1, is located within the LCA4 candidate region. The encoded protein contains three tetratricopeptide motifs, consistent with chaperone or nuclear transport activity. Mutations in this gene may cause approximately 20% of recessive LCA. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Alexa Fluor 647 Alexa Fluor™ 647 (AF647, Alexa 647) has an excitation peak at 650 nm and an emission peak at 665 nm, and is spectrally similar to Cy®5 (GE Healthcare), iFluor® 647 (ATT Bioquest), and DyLight™ 650 (Thermo Fisher Scientific). Alexa 647 is commonly used for flow cytometry, microscopy, super-resolution microscopy applications. It is very bright, photostable, and pH insensitive, all of which contribute to sensitive detection while using this dye.
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Alexa Fluor 647 Excitation and Emission Spectra