Perforin / Vio 667 / REA1061

Citations: (1)
Product Details
Supplier Miltenyi Biotec
Catalog #: 130-118-119 (View supplier product page)
Size 100 tests in 200 µL
Price $395.00
Antigen Perforin
Clone REA1061
Host Human
Isotype IgG1
Conjugate Vio 667
Target Species Human
Applications FC, Mass Cytometry
Description Clone REA1061 recognizes the human perforin, a 70 kDa cytolytic protein, which is expressed by cytotoxic T lymphocytes and natural killer (NK) cells, and which is stored in cytoplasmic granules. Upon cell activation perforin is released and functions as one of the major effector molecule to mediate killing of target cells. | Additional information: Clone REA1061 displays negligible binding to Fc receptors.
About Perforin and Vio 667
Perforin This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood. [provided by RefSeq, Aug 2017]
Vio 667 Vio® 667 from Miltenyi has an excitation peak at 635 nm and an emission peak at 668. It is spectrally comparable to Cy5 and Alexa Fluor™ 647.
Citations
PMID 25998963
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Vio 667 Excitation and Emission Spectra