CD64 / PE-Vio770 / REA286

Citations: (1)
Product Details
Supplier Miltenyi Biotec
Catalog #: 130-119-559 (View supplier product page)
Size 150 µg in 1 mL
Price $485.00
Antigen CD64
Clone REA286
Host Human
Isotype IgG1
Conjugate PE-Vio770
Target Species Mouse
Applications FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC
Description Clone REA286 recognizes the CD64 antigen, a 72 kDa integral membrane glycoprotein also known as high affinity immunoglobulin gamma Fc receptor I (FcγRI). Structurally CD64 is composed of a signal peptide that allows its transport to the surface of a cell, three extracellular immunoglobulin domains of the C2-type that it uses to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail. CD64 is constitutively expressed on macrophages, monocytes, dendritic cells, and mast cells. Treatment with cytokines like IFN-γ and G-CSF induces CD64 upregulation. CD64 binds monomeric IgG-type antibodies with high affinity and mediates endocytosis, phagocytosis, antibody-dependent cellular toxicity, cytokine release, and superoxide generation. | Additional information: Clone REA286 displays negligible binding to Fc receptors. |
Citations
PMID 11911824
PMID 12594281
PMID 16413920
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PE-Vio770 Excitation and Emission Spectra