IL-18 R alpha / Biotin / REA1095

Citations: (2)
Product Details
Supplier Miltenyi Biotec
Catalog #: 130-118-587 (View supplier product page)
Size 100 tests in 200 µL
Price $275.00
Antigen IL-18 R alpha
Clone REA1095
Host Human
Isotype IgG1
Conjugate Biotin
Target Species Human
Applications FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC
Description Clone REA1095 recognizes the CD218 antigen, which is also known as interleukin-18 receptor alpha (IL-18Rα) chain. IL-18 receptor is an heterodimeric receptor complex, and composed of the IL-18Rα chain and the IL-1 receptor accessory protein-like (IL-1RacPL) or IL-18Rβ chain. CD218 represents the ligand-binding chain, whereas IL-18Rβ is suggested to assist in the formation of a high affinity complex and mediates intracellular signals. IL-18R is expressed on a variety of cells including macrophages, neutrophils, natural killer (NK) cells, endothelial, and smooth muscle cells and an upregulated expression is observed on naive T cells, T helper cell type 1 (Tʜ1) cells, and B cells, in the presence IL-12. | Additional information: Clone REA1095 displays negligible binding to Fc receptors.
Citations
PMID 10865972
PMID 11123287
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Biotin Excitation and Emission Spectra