CD16 / PE-Vio615 / REA423

Citations: (5)
Product Details
Supplier Miltenyi Biotec
Catalog #: 130-119-996 (View supplier product page)
Size 30 tests in 60 µL
Price $165.00
Antigen CD16
Clone REA423
Host Human
Isotype IgG1
Conjugate PE-Vio615
Target Species Human
Applications FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC, Mass Cytometry
Description Clone REA423 recognizes the human CD16 antigen, a single-pass type I membrane protein which is also known as low affinity immunoglobulin gamma Fc region receptor III (FcRIII). CD16 is a 50–80 kDa glycoprotein that is expressed in two different isoforms. The transmembrane form is found on human NK cells, macrophages, and mast cells, while the glycosylphosphatidylinositol (GPI)-linked form is present on neutrophils. The human CD16 antigen is a low-affinity receptor for aggregated IgG. The transmembrane form plays a role in signal transduction, NK cell activation, and antibody-dependent cellular cytotoxicity. Clone REA423 recognizes both the extracellular domain of the transmembrane form as well as the GPI-linked form of the human CD16 antigen. CD16 is expressed on the majority of rhesus monkey NK cells and on a subset of monocytes but not on granulocytes. | Additional information: Clone REA423 displays negligible binding to Fc receptors.
Citations
Reviews & Ratings
PE-Vio615 Excitation and Emission Spectra