MMP-12 / Unconjugated /
MMP-12 / Unconjugated /
Product Details
| Supplier | Aviva Systems Biology | |
|---|---|---|
| Catalog #: | OALA05542 (View supplier product page) | |
| Size | 50 μg | |
| Price | $395.00 | |
| Antigen | MMP-12 | |
| Clone | ||
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | Unconjugated | |
| Target Species | Human, Mouse | |
| Applications | IHC-P, WB | |
| Description | MMP12 is a Metallopeptidase M10A type protease. MMP-12 degrads extracellular matrix components such as elastin and is involved in tissue remodeling processes. MMP12 is a proteolytic enzyme responsible for cleavage of plasminogen to angiotensin. Studies using animal models of acute and chronic pulmonary inflammatory diseases, have given evidences that MMP-12 is an important mediator of the pathogenesis of these diseases. |
About MMP-12 and Purified
| MMP-12 | This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease (COPD). This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016] |
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Citations
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