Niemann-Pick C1 / DyLight 488 /

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NB400-148G (View supplier product page)
Size 0.1 ml
Price $499.00
Antigen Niemann-Pick C1
Clone
Host Rabbit
Isotype IgG
Conjugate DyLight 488
Target Species Chinese Hamster, Hamster, Human, Mouse, Porcine, Primate, Rat
Applications WB, IHC-P, ICC/IF, IHC, Knockout Validated, KD
Description Rabbit Niemann-Pick C1 antibody [DyLight 488] detects Human, Mouse, Rat, Porcine, Chinese Hamster, Hamster, Primate
About Niemann-Pick C1 and DyLight 488
Niemann-Pick C1 This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.[provided by RefSeq, Aug 2009]
DyLight 488 DyLight™ 488 has an excitation peak at 493 nm and an emission peak at 518 nm and is spectrally similar to Alexa Fluor™ 488, fluorescein and FITC. DyLight™ 488 is most commonly used in flow cytometery, and fluorescence microscopy applications.
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DyLight 488 Excitation and Emission Spectra