Carbonic Anhydrase VIII / Unconjugated / 1F7
Carbonic Anhydrase VIII / Unconjugated / 1F7
Product Details
| Supplier | Aviva Systems Biology | |
|---|---|---|
| Catalog #: | OAAL00034 (View supplier product page) | |
| Size | 100 μg | |
| Price | $315.00 | |
| Antigen | Carbonic Anhydrase VIII | |
| Clone | 1F7 | |
| Host | Mouse | |
| Isotype | IgG3 κ | |
| Conjugate | Unconjugated | |
| Target Species | Human | |
| Applications | WB, ELISA | |
| Description | CA8 Antibody (OAAL00034) Unconjugated Mouse Monoclonal Antibody, Reacts with Human |
About Carbonic Anhydrase VIII and Purified
| Carbonic Anhydrase VIII | The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in this gene are associated with cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3). Polymorphisms in this gene are associated with osteoporosis, and overexpression of this gene in osteosarcoma cells suggests an oncogenic role. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
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Citations
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