53BP1 / Unconjugated /
53BP1 / Unconjugated /
Product Details
| Supplier | Aviva Systems Biology | |
|---|---|---|
| Catalog #: | OABB01127 (View supplier product page) | |
| Size | 100 μg | |
| Price | $255.00 | |
| Antigen | 53BP1 | |
| Clone | ||
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | Unconjugated | |
| Target Species | Human, Mouse, Rat | |
| Applications | WB, IHC-P, ICC | |
| Description | TP53BP1 Antibody - C-terminal region (OABB01127) Unconjugated Rabbit Polyclonal Antibody, Reacts with Human, Mouse, Rat |
About 53BP1 and Purified
| 53BP1 | This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017] |
|---|
Citations
| Additional Sources |
|
|---|
