ACP2 / Unconjugated / M1-4A12
ACP2 / Unconjugated / M1-4A12
Product Details
| Supplier | Aviva Systems Biology | |
|---|---|---|
| Catalog #: | OALA04933 (View supplier product page) | |
| Size | 50 μg | |
| Price | $450.00 | |
| Antigen | ACP2 | |
| Clone | M1-4A12 | |
| Host | Mouse | |
| Isotype | IgG2b λ | |
| Conjugate | Unconjugated | |
| Target Species | Human | |
| Applications | IHC-P, IF, WB, ELISA | |
| Description | Lysosomal acid phosphatase is comprised of two subunits, alpha and beta, and is chemically and genetically distinct from red cell acid phosphatase. Lysosomal acid phosphatase 2 is a member of a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. Acid phosphatase deficiency is caused by mutations in the ACP2 (beta subunit) and ACP3 (alpha subunit) genes. |
About ACP2 and Purified
| ACP2 | The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene in mice showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2017] |
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Citations
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