RNF111 / Unconjugated /
RNF111 / Unconjugated /
Product Details
| Supplier | Aviva Systems Biology | |
|---|---|---|
| Catalog #: | OAAB17020 (View supplier product page) | |
| Size | 400 μl | |
| Price | $320.00 | |
| Antigen | RNF111 | |
| Clone | ||
| Host | Rabbit | |
| Isotype | Ig | |
| Conjugate | Unconjugated | |
| Target Species | Human, Mouse, Rat | |
| Applications | WB, IHC | |
| Description | Aurora-B (ARK/STK12) antibody - N-terminal region |
About RNF111 and Purified
| RNF111 | The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012] |
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Citations
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