Presenilin-1 / ATTO 594 /

Product Details
Supplier Biorbyt
Catalog #: orb413985-100ug (View supplier product page)
Size 100 μg
Price $575.00
Antigen Presenilin-1
Clone
Host Rabbit
Isotype IgG
Conjugate ATTO 594
Target Species Mouse, Rat
Applications WB
Description Rabbit polyclonal antibody against Presenilin 1 conjugated to ATTO 594
About Presenilin-1 and ATTO 594
Presenilin-1 Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
ATTO 594 ATTO 594 from ATTO-TEC has an excitation peak at 601 nm and an emission peak at 627 nm. ATTO 594 is a novel fluorescent label belonging to the class of rhodamine dyes. Characteristic features of the label are strong absorption, high fluorescence quantum yield, high thermal and photo-stability, and excellent water solubility. Thus ATTO 594 is highly suitable for single-molecule detection applications and high-resolution microscopy such as PALM, dSTORM, STED etc. Additionally the dye highly qualifies to be applied in flow cytometry (FACS), fluorescence in-situ hybridization (FISH) and many more. ATTO 594 is very hydrophilic and shows a very good water solubility. After coupling to a substrate the label carries a net electrical charge of -1.
Citations
Additional
Sources
Reviews & Ratings
Submit a Review

ATTO 594 Excitation and Emission Spectra