Niemann-Pick C1 / Unconjugated / 8D10B6
Niemann-Pick C1 / Unconjugated / 8D10B6
Product Details
| Supplier | Biorbyt | |
|---|---|---|
| Catalog #: | orb153491-100ul (View supplier product page) | |
| Size | 100 μl | |
| Price | $374.00 | |
| Antigen | Niemann-Pick C1 | |
| Clone | 8D10B6 | |
| Host | Mouse | |
| Isotype | IgG1 | |
| Conjugate | Unconjugated | |
| Target Species | Human | |
| Applications | ELISA, WB, IHC-P, IF, ICC, FC | |
| Description | Mouse monoclonal antibody to NPC1 |
About Niemann-Pick C1 and Purified
| Niemann-Pick C1 | This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.[provided by RefSeq, Aug 2009] |
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Images
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Immunohistochemical analysis of formalin-fixed and paraffin-embedded esophageal cancer tissues using NPC1 antibody, Western blot analysis of human NPC1 using NPC1 antibody, Western blot analysis of HEK293 (Lane 1) HEK293 (Lane 2) cell lysate using NPC1 antibody, Immunohistochemical analysis of formalin-fixed and paraffin-embedded striated muscle tissues using NPC1 antibody, Line graph illustrates about the Ag-Ab reactions using different concentrations of antigen and serial dilutions of NPC1 antibody |
Citations
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Purified Excitation and Emission Spectra
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