MUC-1 / PE-Cy5 /

Product Details
Supplier Biorbyt
Catalog #: orb129770-100ug (View supplier product page)
Size 100 μg
Price $451.00
Antigen MUC-1
Clone
Host Rabbit
Isotype IgG
Conjugate PE-Cy5
Target Species Human, Mouse
Applications
Description Rabbit polyclonal to MUC1 (PE-Cy5).
About MUC-1 and PE-Cy5
MUC-1 This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
PE-Cy5 PE-Cyanine®5 (PE-Cy5) is a red-emitting tandem fluorophore that combines phycoerythrin (PE) and Cy5. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Cy5. PE-Cy5 has an excitation peak at 496 nm and an emission peak at 667 nm.
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PE-Cy5 Excitation and Emission Spectra