MSR1 / Unconjugated /
MSR1 / Unconjugated /
Product Details
| Supplier | Biorbyt | |
|---|---|---|
| Catalog #: | orb100585-20ug (View supplier product page) | |
| Size | 20 μg | |
| Price | $85.00 | |
| Antigen | MSR1 | |
| Clone | ||
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | Unconjugated | |
| Target Species | Human, Mouse, Rat | |
| Applications | WB, IHC-P, IF, ICC, FC, ELISA | |
| Description | Rabbit polyclonal antibody to MSR1 |
About MSR1 and Purified
| MSR1 | This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008] |
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Images
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Paraffin-embedded human glioma tissue fixed with 4% paraformaldehyde. Antigen retrieval by boiling with citrate buffer. Blocking buffer is goat serum (37 degrees for 20 min.). MSR1 antibody at 1:200 dilution with overnight incubation at 4 degrees, IHC-P of mouse lung tissue (MSR1 antibody at 1:300), Western blot analysis of human colon carcinoma lysates(Lane1) |
Citations
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Reviews & Ratings
Purified Excitation and Emission Spectra
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