HLA DRB1 / Unconjugated / LN3
HLA DRB1 / Unconjugated / LN3
Product Details
| Supplier | Biorbyt | |
|---|---|---|
| Catalog #: | orb388227-100ug (View supplier product page) | |
| Size | 100 μg | |
| Price | $412.00 | |
| Antigen | HLA DRB1 | |
| Clone | LN3 | |
| Host | Mouse | |
| Isotype | IgG2b,κappa | |
| Conjugate | Unconjugated | |
| Target Species | Human, Monkey | |
| Applications | WB, IHC-P, IF, ICC, FC | |
| Description | Mouse monoclonal antibody to HLA-DRB1 |
About HLA DRB1 and Purified
| HLA DRB1 | HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and some alleles have increased frequencies associated with certain diseases or conditions. For example, DRB1*1302 has been related to acute and chronic hepatitis B virus persistence. There are multiple pseudogenes of this gene. [provided by RefSeq, Jul 2020] |
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Images
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Immunohistochemical staining of human Histiocytoma tissue using HLA-DRB1 antibody, Immunohistochemical staining of human Tonsil tissue using HLA-DRB1 antibody |
Citations
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Reviews & Ratings
Purified Excitation and Emission Spectra
$412.00
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