ErbB2 / Cy5.5 /

Product Details
Supplier Biorbyt
Catalog #: orb123139-100ug (View supplier product page)
Size 100 μg
Price $451.00
Antigen ErbB2
Clone
Host Rabbit
Isotype IgG
Conjugate Cy5.5
Target Species Human, Mouse, Rat
Applications
Description Rabbit polyclonal to ErbB 2 (Cy5.5).
About ErbB2 and Cy5.5
ErbB2 This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Cy5.5 Cy5.5 is an important historical fluorophore from GE Healthcare. It has an excitation peak at 678 nm and an emission peak at 695 nm. Spectrally its similar to Alexa Fluor™ 680.
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Cy5.5 Excitation and Emission Spectra