MSR1 / Biotin / 2F8

Product Details
Supplier Biorbyt
Catalog #: orb432399-25ug (View supplier product page)
Size 25 μg
Price $244.00
Antigen MSR1
Clone 2F8
Host Rat
Isotype IgG2b
Conjugate Biotin
Target Species Mouse
Applications FC
Description Rat monoclonal antibody against CD204 conjugated to Biotin
About MSR1 and Biotin
MSR1 This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
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Biotin Excitation and Emission Spectra