Bcl-10 / Unconjugated / BL10/411

Product Details
Supplier Biorbyt
Catalog #: orb56057-20ug (View supplier product page)
Size 20 μg
Price $374.00
Antigen Bcl-10
Clone BL10/411
Host Mouse
Isotype IgG1 κ
Conjugate Unconjugated
Target Species Human
Applications WB, IHC-P, IF, ICC, FC
Description Mouse monoclonal antibody to Bcl10.
About Bcl-10 and Purified
Bcl-10 This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
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Purified Excitation and Emission Spectra