SREBP1 / Unconjugated /
SREBP1 / Unconjugated /
Product Details
| Supplier | Biorbyt | |
|---|---|---|
| Catalog #: | orb11415-100ug (View supplier product page) | |
| Size | 100 μg | |
| Price | $385.90 | |
| Antigen | SREBP1 | |
| Clone | ||
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | Unconjugated | |
| Target Species | Human, Mouse, Rat | |
| Applications | WB, IHC-P, IF, ELISA | |
| Description | Rabbit polyclonal to SREBP1 |
About SREBP1 and Purified
| SREBP1 | This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively. [provided by RefSeq, Nov 2017] |
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Images
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Immunohistochemical analysis of paraffin-embedded rat pancreas cells, using SREBP1 antibody, IHC-P of rat pancreas cells (SREBP1 antibody at 1:250), Paraffin-embedded rat brain tissue fixed with 4% paraformaldehyde. Antigen retrieval by boiling with citrate buffer. Blocking buffer is goat serum (37 degrees for 20 min.).SREBP1 antibody at 1:200 dilution with overnight incubation at 4 degrees, Paraffin-embedded human colon carcinoma tissue fixed with 4% paraformaldehyde. Antigen retrieval by boiling with citrate buffer. Blocking buffer is goat serum (37 degrees for 20 min.).SREBP1 antibody at 1:200 dilution with overnight incubation at 4 degree, Western blot analysis of rat brain lysates(Lane1, 30ug) and rat lung lysates(Lane2, 30 ug) using SREBP1 antibody |
Citations
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