PRDM9 / Unconjugated /

Product Details
Supplier OriGene
Catalog #: TA339515 (View supplier product page)
Size 50 μg
Price $360.00
Antigen PRDM9
Clone
Host Rabbit
Isotype IgG
Conjugate Unconjugated
Target Species Human
Applications WB, IHC
Description Rabbit Polyclonal Anti-PRDM9 Antibody
About PRDM9 and Purified
PRDM9 The protein encoded by this gene is a zinc finger protein with histone methyltransferase activity that catalyzes histone H3 lysine 4 trimethylation (H3K4me3) during meiotic prophase. This protein contains multiple domains, including a Kruppel-associated box (KRAB) domain, an SSX repression domain (SSXRD), a PRD1-BF1 and RIZ homologous region, a subclass of SET (PR/SET) domain, and a tandem array of C2H2 zinc fingers. The zinc finger array recognizes a short sequence motif, leading to local H3K4me3, and meiotic recombination hotspot activity. The observed allelic variation alters the DNA-binding sequence specificity of the protein, resulting in distinct meiotic recombination hotspots amongst individuals and populations. Multiple alternate alleles of this gene have been described. [provided by RefSeq, Jul 2015]
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Purified Excitation and Emission Spectra